曲马多作为利多卡因辅助剂用于腋路臂丛神经阻滞。
Tramadol as an adjuvant to lidocaine for axillary brachial plexus block.
作者信息
Kaabachi Olfa, Ouezini Rami, Koubaa Walid, Ghrab Badii, Zargouni Amin, Ben Abdelaziz Ahmed
机构信息
Service d'anesthésie réanimation, Institut Kassab d'Orthopédie, Ksar said, Tunis, Tunisia.
出版信息
Anesth Analg. 2009 Jan;108(1):367-70. doi: 10.1213/ane.0b013e31818e0c6b.
BACKGROUND
In this prospective randomized study, we evaluated the effect of tramadol as an adjuvant to axillary block.
METHODS
We studied 102 patients scheduled for hand surgery under axillary block with lidocaine 1.5% (epinephrine 1/200,000) and the addition of either 4 mL saline (control group), 100 mg tramadol and 2 mL saline (TL group), or 200 mg tramadol (TH group).
RESULTS
Onset time was longer in the TH group, 16 +/- 7 min (9 +/- 3 min in control group; P = 0.01). Sensory block and time for first rescue analgesia were significantly prolonged in the TH group compared with both TL and control groups (265 +/- 119 min vs 190 +/- 87 min vs 126 +/- 48 min; P = 0.018); (734 +/- 434 min vs 573 +/- 516 min vs 375 +/- 316 min; P = 0.02).
CONCLUSIONS
The benefit of block prolongation associated with the addition of 200 mg tramadol to lidocaine during axillary block is limited by the slow onset of the block.
背景
在这项前瞻性随机研究中，我们评估了曲马多作为腋路阻滞辅助药物的效果。
方法
我们研究了102例计划在腋路阻滞下进行手部手术的患者，使用1.5%利多卡因（肾上腺素1/200,000），并分别添加4毫升生理盐水（对照组）、100毫克曲马多和2毫升生理盐水（TL组）或200毫克曲马多（TH组）。
结果
TH组的起效时间更长，为16±7分钟（对照组为9±3分钟；P = 0.01）。与TL组和对照组相比，TH组的感觉阻滞时间和首次补救镇痛时间显著延长（265±119分钟对190±87分钟对126±48分钟；P = 0.018）；（734±434分钟对573±516分钟对375±316分钟；P = 0.02）。
结论
在腋路阻滞期间，向利多卡因中添加200毫克曲马多所带来的阻滞延长益处受到阻滞起效缓慢的限制。
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