Khurana Vikram
Department of Neurology, Massachusetts General and Brigham and Women's Hospitals, Boston, MA 02115, USA.
J Alzheimers Dis. 2008 Dec;15(4):541-53. doi: 10.3233/jad-2008-15403.
The fruit fly Drosophila melanogaster has emerged as a powerful system in which to model human disease. This review focuses on the utility of the fly to model tau-dependent neurodegeneration, a hallmark of Alzheimer's disease and related neurodegenerative disorders. I provide a detailed description of fly tauopathy models and summarize a number of studies that demonstrate their ability to recapitulate both primary features of tauopathy, including tau-induced neurodegeneration and phosphorylation, and secondary features, including oxidative stress, cell-cycle activation and changes in the actin cytoskeleton. Important genetic and biochemical insights are discussed, and future directions proposed.
果蝇已成为一种用于模拟人类疾病的强大系统。本综述聚焦于果蝇在模拟tau蛋白相关神经退行性变方面的效用，tau蛋白相关神经退行性变是阿尔茨海默病及相关神经退行性疾病的一个标志。我详细描述了果蝇tau蛋白病模型，并总结了多项研究，这些研究表明它们能够重现tau蛋白病的主要特征，包括tau蛋白诱导的神经退行性变和磷酸化，以及次要特征，包括氧化应激、细胞周期激活和肌动蛋白细胞骨架的变化。文中讨论了重要的遗传学和生物化学见解，并提出了未来的研究方向。
