Chung Hyun-Tai, Chung Young Seob, Kim Dong Gyu, Paek Sun Ha, Cho Keun-Tae
Department of Neurosurgery , Seoul National University, College of Medicine, Seoul, Korea.
J Korean Neurosurg Soc. 2008 Jan;43(1):26-30. doi: 10.3340/jkns.2008.43.1.26. Epub 2008 Jan 20.
The authors developed a stereotactic device for irradiation of small animals with Leksell Gamma Knife(R) Model C. Development and verification procedures were described in this article.
The device was designed to satisfy three requirements. The mechanical accuracy in positioning was to be managed within 0.5 mm. The strength of the device and structure were to be compromised to provide enough strength to hold a small animal during irradiation and to interfere the gamma ray beam as little as possible. The device was to be used in combination with the Leksell G-frame(R) and KOPF(R) rat adaptor. The irradiation point was determined by separate imaging sequences such as plain X-ray images.
The absolute dose rate with the device in a Leksell Gamma Knife was 3.7% less than the value calculated from Leksell Gamma Plan(R). The dose distributions measured with GAFCHROMIC(R) MD-55 film corresponded to those of Leksell Gamma Plan(R) within acceptable range. The device was used in a series of rat experiments with a 4 mm helmet of Leksell Gamma Knife.
A stereotactic device for irradiation of small animals with Leksell Gamma Knife Model C has been developed so that it fulfilled above requirements. Absorbed dose and dose distribution at the center of a Gamma Knife helmet are in acceptable ranges. The device provides enough accuracy for stereotactic irradiation with acceptable practicality.
作者开发了一种用于使用Leksell伽玛刀C型对小动物进行照射的立体定向装置。本文描述了其开发和验证过程。
该装置的设计满足三个要求。定位的机械精度要控制在0.5毫米以内。装置的强度和结构要在保证在照射期间能为固定小动物提供足够强度的同时，尽可能少地干扰伽马射线束。该装置要与Leksell G型框架和KOPF大鼠适配器结合使用。照射点通过单独的成像序列如普通X射线图像来确定。
在Leksell伽玛刀中使用该装置时的绝对剂量率比从Leksell伽玛计划计算得出的值低3.7%。用GAFCHROMIC MD - 55胶片测量的剂量分布与Leksell伽玛计划的剂量分布在可接受范围内相符。该装置用于一系列使用Leksell伽玛刀4毫米准直器的大鼠实验。
已开发出一种用于使用Leksell伽玛刀C型对小动物进行照射的立体定向装置，使其满足上述要求。伽玛刀准直器中心的吸收剂量和剂量分布在可接受范围内。该装置为立体定向照射提供了足够的精度且具有可接受的实用性。
