Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
PPAR Res. 2008;2008:794814. doi: 10.1155/2008/794814. Epub 2008 Dec 16.
Peroxisome proliferator-activated receptor delta (PPARdelta, also known as PPARbeta) has ubiquitous distribution and extensive biological functions. The reproductive function of PPARdelta was first revealed in the uterus at the implantation site. Since then, PPARdelta and its ligand have been discovered in all reproductive tissues, including the gametes and the preimplantation embryos. PPARdelta in preimplantation embryos is normally activated by oviduct-derived PPARdelta ligand. PPARdelta activation is associated with an increase in embryonic cell proliferation and a decrease in programmed cell death (apoptosis). On the other hand, the role of PPARdelta and its ligand in gamete formation and function is less well understood. This review will summarize the reproductive functions of PPARdelta and project its potential applications in assisted reproductive technology.
过氧化物酶体增殖物激活受体 δ（PPARδ，也称为 PPARβ）分布广泛，具有广泛的生物学功能。PPARδ 的生殖功能最初是在着床部位的子宫中发现的。从那时起，PPARδ 及其配体已在所有生殖组织中被发现，包括配子和着床前胚胎。着床前胚胎中的 PPARδ 通常被输卵管衍生的 PPARδ 配体激活。PPARδ 的激活与胚胎细胞增殖增加和程序性细胞死亡（细胞凋亡）减少有关。另一方面，PPARδ 及其配体在配子形成和功能中的作用还不太清楚。这篇综述将总结 PPARδ 的生殖功能，并预测其在辅助生殖技术中的潜在应用。
