Boury-Jamot Mathieu, Daraspe Jean, Bonté Frédéric, Perrier Eric, Schnebert Sylvianne, Dumas Marc, Verbavatz Jean-Marc
IBITEC-S and CNRS URA 2096, CEA-Saclay F-91191 Gif-sur-Yvette and LRA17V, University Paris-Sud 11, Orsay, F-91400, France.
Handb Exp Pharmacol. 2009(190):205-17. doi: 10.1007/978-3-540-79885-9_10.
Several aquaporins (AQPs) are expressed in mammalian skin. Some are directly involved in water transport, such as AQP5, which is involved in sweat secretion. In contrast, the physiological role of skin aquaglyceroporins, which permeate both water and glycerol, appears more and more complex. AQP3 is the most abundant skin aquaglyceroporin. Both water and glycerol transport by AQP3 appear to play an important role in hydration of mammalian skin epidermis. In addition, recent data suggest that glycerol transport by AQP3 is involved in the metabolism of lipids in skin as well as in the regulation of proliferation and differentiation of keratinocytes. Finally, AQP3 is also believed to be important in wound healing, as a water channel by facilitating cell migration, and as a glycerol transporter by enhancing keratinocyte proliferation and differentiation.
几种水通道蛋白（AQP）在哺乳动物皮肤中表达。有些直接参与水的运输，如参与汗液分泌的AQP5。相比之下，既能通透水又能通透甘油的皮肤水甘油通道蛋白的生理作用似乎越来越复杂。AQP3是皮肤中含量最丰富的水甘油通道蛋白。AQP3对水和甘油的运输似乎在哺乳动物皮肤表皮的水合作用中都发挥着重要作用。此外，最近的数据表明，AQP3对甘油的运输还参与皮肤脂质代谢以及角质形成细胞增殖和分化的调节。最后，AQP3还被认为在伤口愈合中很重要，它作为水通道促进细胞迁移，作为甘油转运体增强角质形成细胞的增殖和分化。
