哺乳动物水通道蛋白的新成员：水通道蛋白10 - 水通道蛋白12。

New members of mammalian aquaporins: AQP10-AQP12.

作者信息

Ishibashi Kenichi

机构信息

Department of Medical Physiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan.

出版信息

Handb Exp Pharmacol. 2009(190):251-62. doi: 10.1007/978-3-540-79885-9_13.

DOI:10.1007/978-3-540-79885-9_13

PMID:19096782

Abstract

Thirteen members of mammalian aquaporins have been identified. Initial ten members (AQP-AQP9) are relatively well detailed and their roles are clarified. However, the last three members, AQP10-AQP12, are poorly characterized and little is known about their roles though they were cloned 6 years ago. In this review, we focus on these three AQPs. AQP10 is an aquaglyceroporin while AQP11 and AQP12 belong to a new subfamily, superaquaporins. Knockout mice for these aquaporins are now available. The AQP11 null mouse has a remarkable phenotype, polycystic kidneys, which is neonatally fatal. On the other hand, the absence of the other two affected little. In some animals, AQP10 is even a pseudogene. This review summarizes the current knowledge on these AQPs and will hopefully stimulate future research on the subject.

摘要

哺乳动物水通道蛋白已鉴定出13个成员。最初的10个成员（AQP1 - AQP9）研究得相对详细，其作用也已明确。然而，最后三个成员，即AQP10 - AQP12，特征描述较少，尽管它们在6年前就已克隆，但对其作用知之甚少。在本综述中，我们聚焦于这三种水通道蛋白。AQP10是一种水甘油通道蛋白，而AQP11和AQP12属于一个新的亚家族——超级水通道蛋白。目前已有这些水通道蛋白的基因敲除小鼠。AQP11基因敲除小鼠具有显著的表型——多囊肾，这在新生期是致命的。另一方面，另外两种水通道蛋白缺失的影响较小。在一些动物中，AQP10甚至是一个假基因。本综述总结了目前关于这些水通道蛋白的知识，有望激发该领域未来的研究。