Rodríguez Ignacio, Pérez-Sánchez José Manuel, Peces-Barba Germán, Kaulisch Thomas, Stiller Detlef, Ruiz-Cabello Jesús
Departamento de Química Física II, Facultad de Farmacia, Universidad Complutense Madrid, CIBER de enfermedades respiratorias, Madrid, Spain.
Magn Reson Med. 2009 Jan;61(1):54-8. doi: 10.1002/mrm.21826.
Based on a stimulated-echo technique, a method to construct an apparent diffusion coefficient (ADC) map of hyperpolarized (3)He in a long-range diffusion scale is presented with a phase-cycle alternative to remove all unwanted echoes. The approach was successfully applied to determine in vivo diffusion constants in rat lungs. The ADC values in healthy rats show a good agreement with reported values for diffusion times of approximately. These long diffusivity measurements may be sensitive to detect emphysema progression or tissue remodeling and thus have enormous potential for the diagnosis and tracking of disease progression and for drug evaluation.
基于受激回波技术，提出了一种在长程扩散尺度上构建超极化（3）He表观扩散系数（ADC）图的方法，该方法采用相位循环来消除所有不需要的回波。该方法已成功应用于测定大鼠肺脏的体内扩散常数。健康大鼠的ADC值与报道的大约扩散时间的值吻合良好。这些长扩散率测量对于检测肺气肿进展或组织重塑可能很敏感，因此在疾病进展的诊断和跟踪以及药物评估方面具有巨大潜力。
