Taran Katarzyna, Kobos Józef, Sporny Stanisław
Department of Pathology, Medical University of Łódz.
Pol J Pathol. 2008;59(3):177-82.
In spite of success of modern pediatric oncology, cases in which we are not able to reach the prospective affirmative effect of performed therapy are still observed. The purpose of our study was to examine the expression of WT1 gene product and CD44 adhesive molecule in nephroblastoma histologic types - one of the currently used prognostic marker for this group of tumor. We found correlations between CD44 expression and histologic type of tumor. We suppose that high CD44 expression in nephroblastoma group of tumors may confirm their high malignant potential. Expression of the WT1 gene product we found in all the investigated tumor tissue samples. However we did not found statistically significant correlations between WT1 expression and histologic type of the tumor and there was no correlation between CD44 and WT1 expression in blastemal nor of epithelial component of nephroblastoma in our study. Lack of this correlation also permits to suppose that the high activity is an integral feature of all Wilms tumor cells and is not only characteristic for anaplastic and blastemal nephroblastomas.
尽管现代小儿肿瘤学取得了成功，但仍有一些病例，我们无法达到所实施治疗的预期肯定效果。我们研究的目的是检测WT1基因产物和CD44黏附分子在肾母细胞瘤组织学类型中的表达——这是目前用于该组肿瘤的预后标志物之一。我们发现CD44表达与肿瘤组织学类型之间存在相关性。我们推测，肾母细胞瘤组肿瘤中CD44的高表达可能证实其具有较高的恶性潜能。我们在所有研究的肿瘤组织样本中都发现了WT1基因产物的表达。然而，我们没有发现WT1表达与肿瘤组织学类型之间存在统计学上的显著相关性，并且在我们的研究中，肾母细胞瘤的胚芽成分或上皮成分中，CD44与WT1表达之间也没有相关性。这种相关性的缺乏也使我们推测，高活性是所有肾母细胞瘤细胞的一个固有特征，而不仅仅是间变性和胚芽性肾母细胞瘤的特征。
