Cada Z, Plzák J, Chovanec M, Dvoránková B, Lacina L, Szabó P, Smetana K, Betka J
Karlova Univerzita, 1. lékarská fakulta, Anatomický ústav, Praha.
Cas Lek Cesk. 2008;147(11):559-63.
Cancers of head and neck represents about 5% of all tumors. 80 to 90% of these tumors are constituted of squamous cell carcinomas. Despite a rapid progress in diagnostics and therapy the overall 5-year survival of this type of cancer is among the lowest of the major cancer types. This unfavourable situation needs the extensive research to found new markers to better characterize biological behavior of tumors as a rational background for more sophisticated therapeutic modalities. Among the most promising markers are endogenous lectins called galectins and their ligands. Especially galectin-1, -3 and -7 play a key role in pathology of squamous cell carcinomas.
头颈部癌症约占所有肿瘤的5%。这些肿瘤中80%至90%由鳞状细胞癌构成。尽管在诊断和治疗方面取得了快速进展，但这类癌症的总体5年生存率在主要癌症类型中是最低的之一。这种不利情况需要进行广泛研究以找到新的标志物，从而更好地表征肿瘤的生物学行为，为更复杂的治疗方式提供合理依据。最有前景的标志物之一是内源性凝集素，即半乳糖凝集素及其配体。特别是半乳糖凝集素-1、-3和-7在鳞状细胞癌的病理过程中起关键作用。
