使用基于奥林巴斯F(ab')2的试剂消除异嗜性抗体对铁蛋白检测的干扰。
Eliminating heterophilic antibody interference for ferritin detection using Olympus F(ab')2 based reagent.
作者信息
Grouzmann Eric, Dayer Nicole, Bain Catherine, Neville Claire M, McCusker Matthew D, Wang Robert Y
机构信息
Laboratoires Meditest SA, 1800, Vevey, Switzerland.
出版信息
Clin Lab. 2008;54(9-10):355-7.
PMID:19097493
Abstract
Interferences with the Olympus immunoturbidimetric assay for ferritin have been reported because the antibodies used in the immunoassay are derived from rabbits. Rabbits are familiar pets known to be a risk factor for developing heterophilic (or interfering) antibodies. This report shows how the current Olympus Ferritin assay has been improved to eliminate the interference from heterophilic antibodies.
摘要
据报道，用于铁蛋白检测的奥林巴斯免疫比浊法存在干扰，因为该免疫分析中使用的抗体来源于兔子。兔子是常见宠物，已知是产生嗜异性（或干扰性）抗体的一个风险因素。本报告展示了当前奥林巴斯铁蛋白检测方法是如何改进以消除嗜异性抗体干扰的。
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