Kilic S, Moraloglu O, Yuksel B, Ozaksit G, Tasdemir N, Dogan M
Department of Reproductive Endocrinology, Dr. Zekai Tahir Burak Women's Health and Research, Hospital, Ankara, Turkey.
J Reprod Immunol. 2009 Jan;79(2):211-4. doi: 10.1016/j.jri.2008.10.002. Epub 2008 Dec 20.
Obesity causes the specific upregulation of proinflammatory cytokines and chemokines. One of these cytokines, IL-18, has a well-known association with obesity. Our aim in this study was to test the effect of serum and intrafollicular IL-18 and IL-18 binding protein (BP) levels on in vitro fertilization outcomes in obese, overweight, and non-obese patients. Serum and pooled follicular fluid levels of IL-18, IL-18BP, and the IL-18/IL-18BP ratios were evaluated in 21 non-obese (body mass index [BMI] <25), 37 overweight (25<or=BMI<30), and 24 obese (BMI>or=30) patients undergoing in vitro fertilization. IL-18 and IL-18BP levels in serum and follicular fluid did not change with obesity. There was no correlation among serum intrafollicular IL-18, IL-18BP levels, and the number of oocytes retrieved and transferred, embryo grades or pregnancy ratios. The levels of serum and intrafollicular IL-18, IL-18BP, and the IL-18/IL-18BP ratios do not seem to be related to in vitro fertilization outcomes in obese, overweight, and non-obese patients.
肥胖会导致促炎细胞因子和趋化因子的特异性上调。其中一种细胞因子白细胞介素18（IL-18）与肥胖有着众所周知的关联。本研究的目的是检测血清和卵泡内IL-18及IL-18结合蛋白（BP）水平对肥胖、超重及非肥胖患者体外受精结局的影响。对21例非肥胖（体重指数[BMI]<25）、37例超重（25≤BMI<30）及24例肥胖（BMI≥30）且正在接受体外受精的患者的血清和卵泡液中IL-18、IL-18BP水平及IL-18/IL-18BP比值进行了评估。血清和卵泡液中的IL-18及IL-18BP水平不会因肥胖而改变。血清和卵泡内的IL-18、IL-18BP水平与获取及移植的卵母细胞数量、胚胎等级或妊娠率之间没有相关性。血清和卵泡内的IL-18、IL-18BP水平及IL-18/IL-18BP比值似乎与肥胖、超重及非肥胖患者的体外受精结局无关。
