Wang Qiu-yue, Chen Fen-qin
Department of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Diabetes Res Clin Pract. 2009 Feb;83(2):215-9. doi: 10.1016/j.diabres.2008.09.048. Epub 2008 Dec 20.
Monocyte chemoattractant protein-1(MCP-1) is a cytokine that exhibits most potent chemotactic activity toward monocytes. It is suggested to be implicated in the development and progression of diabetic nephropathy by playing a role in infiltration of monocyte/macrophage. Recent studies have demonstrated that urinary monocyte chemoattractant protein-1 (uMCP-1) is different at different stages of diabetic nephropathy. Based on these findings, the aim of this study is to examine the level of uMCP-1 and its clinical significance at different stages of diabetic nephropathy and at the same time to describe the relationship between uMCP-1 and the various parameters.
Fifty-nine cases with type 2 diabetes mellitus (T2DM) were divided into three groups according to urine albumin excretion (UAE): normal albuminuria group, microalbuminuria group and macroalbuminuria group. The levels of uMCP-1, protein excretion, blood urea nitrogen (BUN), serum creatinine (s-Cr), glycohemoglobin A1c (HbA1c), blood pressure and blood fat were measured in 59 patients with T2DM and 27 healthy adults as controls. Results Compared with normal control, levels of uMCP-1 in T2DM were significantly high, which were already elevated in normal albuminuria group. Compared with normal albuminuria group, levels of uMCP-1 in microalbuminuria group and macroalbuminuria group were significantly high. Levels of uMCP-1 in macroalbuminuria group were higher than those in microalbuminuria group. The level of uMCP-1 was positively correlated with UAE, systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) in T2DM patients, while it had no significant correlation with HbA1c(,) triglyceride (TG) and high density lipoprotein cholesterol (HDL-C).
MCP-1 is suggested to be implicated in the development and progression of diabetic nephropathy. It is very important to measure the level of uMCP-1 in the diagnosis and intervention of early diabetic nephropathy.
单核细胞趋化蛋白-1（MCP-1）是一种对单核细胞具有最强趋化活性的细胞因子。有研究表明，它通过在单核细胞/巨噬细胞浸润中发挥作用，参与糖尿病肾病的发生和发展。最近的研究表明，糖尿病肾病不同阶段的尿单核细胞趋化蛋白-1（uMCP-1）有所不同。基于这些发现，本研究旨在检测糖尿病肾病不同阶段uMCP-1的水平及其临床意义，同时描述uMCP-1与各项参数之间的关系。
将59例2型糖尿病（T2DM）患者根据尿白蛋白排泄率（UAE）分为三组：正常蛋白尿组、微量白蛋白尿组和大量白蛋白尿组。测定59例T2DM患者和27例健康成年人（作为对照）的uMCP-1水平、蛋白排泄量、血尿素氮（BUN）、血清肌酐（s-Cr）、糖化血红蛋白A1c（HbA1c）、血压和血脂。结果与正常对照组相比，T2DM患者的uMCP-1水平显著升高，在正常蛋白尿组中就已升高。与正常蛋白尿组相比，微量白蛋白尿组和大量白蛋白尿组的uMCP-1水平显著升高。大量白蛋白尿组的uMCP-1水平高于微量白蛋白尿组。T2DM患者的uMCP-1水平与UAE、收缩压（SBP）、舒张压（DBP）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）呈正相关，而与HbA1c、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）无显著相关性。
提示MCP-1参与糖尿病肾病的发生和发展。检测uMCP-1水平对早期糖尿病肾病的诊断和干预非常重要。
