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[儿童睡眠呼吸障碍]

[Sleep-disordered breathing in children].

作者信息

Cohen-Gogo S, Do Ngoc Thanh C, Levy D, Métreau J, Mornand P, Parisot P, Fauroux B

机构信息

Service de génétique médicale, hôpital Necker-Enfants-Malades, AP-HP, Paris, France.

出版信息

Arch Pediatr. 2009 Feb;16(2):123-31. doi: 10.1016/j.arcped.2008.11.016. Epub 2008 Dec 20.

Abstract

Sleep-disordered breathing (SDB) in children comprises a wide spectrum of symptoms ranging from primary snoring to obstructive sleep apnea (OSA). Twelve percent of children present primary snoring and 1-2% OSA. Polysomnography is the gold standard for diagnosis of SDB allowing the analysis of sleep stages, respiratory movements, airflow, and gas exchange. However, this test remains highly technical, expensive, and difficult to conduct; other simpler diagnostic methods are under evaluation. Recent studies highlight the frequency and importance of cognitive and behavioral disorders in children with SDB; both the age and the severity of the SDB seem to modulate in the expression of neurocognitive consequences. Local and systemic inflammation plays a key role in the physiopathology of SDB and its complications: OSA is a cardiovascular risk factor in childhood that could favor atheromatous complications later in life. Adenoidotonsillectomy is the treatment of choice, but anti-inflammatory therapies such as leukotriene receptor antagonists or nasal corticoids may be beneficial in mild SDB or in residual OSA after adenotonsillectomy. In case of failure, noninvasive ventilation by means of nasal continuous positive pressure will be necessary, aided by specialists. SDB and OSA are a public health problem, underlining the pivotal role of the pediatrician in preventing, diagnosing, and treating these frequent disorders.

摘要

儿童睡眠呼吸障碍(SDB)包括从原发性打鼾到阻塞性睡眠呼吸暂停(OSA)等一系列广泛的症状。12%的儿童存在原发性打鼾,1%-2%的儿童存在OSA。多导睡眠图是诊断SDB的金标准,可用于分析睡眠阶段、呼吸运动、气流和气体交换。然而,这项检查技术要求高、费用昂贵且操作困难;其他更简单的诊断方法正在评估中。最近的研究强调了SDB患儿认知和行为障碍的发生率及重要性;SDB的年龄和严重程度似乎都在调节神经认知后果的表现。局部和全身炎症在SDB及其并发症的病理生理过程中起关键作用:OSA是儿童期的心血管危险因素,可能会增加日后发生动脉粥样硬化并发症的风险。腺样体扁桃体切除术是首选治疗方法,但白三烯受体拮抗剂或鼻用糖皮质激素等抗炎治疗可能对轻度SDB或腺样体扁桃体切除术后残留的OSA有益。如果治疗失败,则需要在专家的协助下通过鼻持续正压通气进行无创通气。SDB和OSA是一个公共卫生问题,凸显了儿科医生在预防、诊断和治疗这些常见疾病方面的关键作用。

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