用氯铝酞菁进行光动力疗法可诱导小鼠舌肿瘤发生坏死和血管损伤。

Photodynamic therapy with aluminum-chloro-phthalocyanine induces necrosis and vascular damage in mice tongue tumors.

作者信息

Longo João Paulo Figueiró, Lozzi Silene Paulino, Simioni Andreza Ribeiro, Morais Paulo César, Tedesco Antônio Cláudio, Azevedo Ricardo Bentes

机构信息

Department of Genetics and Morphology, Institute of Biology, University of Brasília, Brasília DF 70910-900, Brazil.

出版信息

J Photochem Photobiol B. 2009 Feb 9;94(2):143-6. doi: 10.1016/j.jphotobiol.2008.11.003. Epub 2008 Nov 21.

DOI:10.1016/j.jphotobiol.2008.11.003

PMID:19097802

Abstract

In this paper we describe the efficacy of the liposomal-AlClPc (aluminum-chloro-phthalocyanine) formulation in PDT study against Ehrlich tumor cells proliferation in immunocompetent swiss mice tongue. Experiments were conduced in sixteen tumor induced mice that were divided in three control groups: (1) tumor without treatment; (2) tumor with 100J/cm(2) laser (670nm) irradiation; and (3) tumor with AlClPc peritumoral injection; and a PDT experimental group when tumors received AlClPc injection followed by tumor irradiation. Control groups present similar macroscopically and histological patterns after treatments, while PDT treatment induced 90% of Ehrlich tumor necrosis after 24h of one single application, showing the efficacy of liposome-AlClPc (aluminum-chloro-phthalocyanine) mediated PDT on the treatment of oral cancer.

摘要

在本文中，我们描述了脂质体-氯铝酞菁（AlClPc）制剂在光动力疗法（PDT）研究中对免疫健全的瑞士小鼠舌部艾氏瘤细胞增殖的疗效。实验在16只诱发肿瘤的小鼠中进行，这些小鼠被分为三个对照组：（1）未治疗的肿瘤组；（2）接受100J/cm²激光（670nm）照射的肿瘤组；（3）瘤周注射AlClPc的肿瘤组；以及一个光动力疗法实验组，即肿瘤接受AlClPc注射后再进行肿瘤照射。治疗后，对照组在宏观和组织学模式上相似，而光动力疗法治疗在单次应用24小时后导致90%的艾氏瘤坏死，显示了脂质体-氯铝酞菁（AlClPc）介导的光动力疗法在口腔癌治疗中的疗效。