pH 响应型核壳纳米载体的构建及其在治疗药物和诊断试剂递送上的应用。
Development of pH-responsive core-shell nanocarriers for delivery of therapeutic and diagnostic agents.
机构信息
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany.
出版信息
Bioorg Med Chem Lett. 2009 Feb 1;19(3):1030-4. doi: 10.1016/j.bmcl.2008.01.043. Epub 2008 Jan 18.
In this paper new dendritic core-shell architectures with pH-labile linkers based on hyperbranched polyglycerol cores and biocompatible poly(ethylene glycol) shells were synthesized which encapsulate the anticancer agent doxorubicin and a dye for near-infrared imaging, an indotricarbocyanine. Acid-sensitive properties of the new nanocarriers and in vitro cytotoxicity of the doxorubicin-nanocarrier are presented as well as preliminary data regarding their toxicity and tumor targeting potential in nude mice.
本文合成了具有 pH 敏感性连接键的新型树枝状核壳结构纳米载体，该载体以超支化聚甘油核和生物相容性聚乙二醇壳为基础，包裹了抗癌药物阿霉素和近红外成像染料吲哚菁绿。本文介绍了新型纳米载体的酸敏特性和载阿霉素纳米载体的体外细胞毒性，以及它们在裸鼠体内毒性和肿瘤靶向潜力的初步数据。
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