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颞浅动脉-大脑中动脉搭桥术治疗有症状的颈动脉闭塞和血流动力学损害。

STA-MCA bypass for symptomatic carotid occlusion and haemodynamic impairment.

作者信息

Jeffree Rosalind L, Stoodley Marcus A

机构信息

Institute of Neurological Sciences, Prince of Wales Hospital, High St, Randwick, New South Wales, 2031, Australia.

出版信息

J Clin Neurosci. 2009 Feb;16(2):226-35. doi: 10.1016/j.jocn.2008.01.022. Epub 2008 Dec 18.

Abstract

Patients with carotid artery occlusion and haemodynamic insufficiency have a high risk of stroke. Cerebral revascularization surgery improves cerebral blood flow, but it remains unclear whether this reduces the risk of stroke. This study assesses the long-term outcome of patients undergoing superficial temporal artery to middle cerebral artery (STA-MCA) bypass for symptomatic carotid occlusion. The long-term clinical follow-up and haemodynamic reserve, measured by (99)Technetium single photon emission computed tomography (Tc99 SPECT) scan with acetazolamide challenge, were reviewed for 19 consecutive patients before and after STA-MCA bypass. The stroke rate after bypass surgery was 8% per year. In patients waiting for surgery, the stroke rate was 18% per year. Cerebral perfusion assessed with SPECT scan improved in 88% of patients. These results are consistent with the high risks of haemodynamic infarction in untreated patients and a benefit from revascularization surgery. The percentage annual stroke risk compares favourably with an 18% rate reported for patients with internal carotid artery occlusion and impaired cerebrovascular reserve.

摘要

患有颈动脉闭塞和血流动力学不足的患者中风风险很高。脑血运重建手术可改善脑血流量,但尚不清楚这是否能降低中风风险。本研究评估了因症状性颈动脉闭塞接受颞浅动脉至大脑中动脉(STA-MCA)搭桥手术患者的长期预后。对19例连续患者在STA-MCA搭桥手术前后进行了长期临床随访,并通过(99)锝单光子发射计算机断层扫描(Tc99 SPECT)加乙酰唑胺激发试验测量了血流动力学储备。搭桥手术后的年中风率为8%。在等待手术的患者中,年中风率为18%。通过SPECT扫描评估,88%的患者脑灌注得到改善。这些结果与未经治疗患者发生血流动力学梗死的高风险以及血运重建手术的益处相一致。每年的中风风险百分比与报道的颈内动脉闭塞和脑血管储备受损患者18%的中风率相比更有利。

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