Thau K, Meszaros K, Simhandl C
Department of Psychiatry, University of Vienna, Austria.
Pharmacopsychiatry. 1991 May;24(3):85-8. doi: 10.1055/s-2007-1014445.
Three female patients suffering from severe mania, who failed to respond to increasingly high dosages of highly potent neuroleptics, were put on a high-dose regime of lithium carbonate. With rapidly increasing daily doses of lithium carbonate, blood levels of approximately 1.3-1.51 mmol/l were achieved. When high lithium levels had been attained the patients showed a considerable improvement between 75 and 82 percent on the Bech-Rafaelsen Scale. At the same time it proved possible to reduce additional medication. Not toxic effects of lithium carbonate were observed. The consequences for clinical practice (e.g. shortened duration of hospitalization) are discussed.
三名患有严重躁狂症的女性患者，对逐渐增加剂量的高效神经阻滞剂无反应，于是接受了高剂量的碳酸锂治疗方案。随着碳酸锂日剂量迅速增加，血液浓度达到了约1.3 - 1.51毫摩尔/升。当达到高锂水平时，患者在Bech-Rafaelsen量表上的改善程度达到了75%至82%。与此同时，事实证明可以减少额外用药。未观察到碳酸锂的毒性作用。文中讨论了这一结果对临床实践的影响（如缩短住院时间）。
