Khosravani Houman, Zhang Yunfeng, Zamponi Gerald W
Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Prion. 2008 Apr-Jun;2(2):48-50. doi: 10.4161/pri.2.2.6628. Epub 2008 Apr 16.
Cellular prion protein (PrP(C)) appears to be involved in numerous physiological processes. We have recently shown a novel modulation of NMDA receptors by PrP(C) that results in neuroprotection via silencing of NMDA receptors containing NR2D subunits, whereas no effects on AMPA receptor function could be observed (Khosravani, et al. J Cell Biol 2008; 181:551). Here we show that PrP-null mice show a normal response to long-term depression stimuli requiring AMPA receptor activity, thus further supporting our previous findings of a selective action on NMDA receptors among ionotropic glutamate receptors.
细胞朊蛋白（PrP(C)）似乎参与了众多生理过程。我们最近发现PrP(C)对N-甲基-D-天冬氨酸受体（NMDA受体）具有一种新型调节作用，该作用通过沉默含有NR2D亚基的NMDA受体实现神经保护，而对α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体（AMPA受体）功能未观察到影响（霍斯拉瓦尼等人，《细胞生物学杂志》2008年；181:551）。在此我们表明，PrP基因敲除小鼠对需要AMPA受体活性的长期抑郁刺激表现出正常反应，从而进一步支持了我们之前关于离子型谷氨酸受体中对NMDA受体有选择性作用的发现。
