Cancer gene silencing without DNA hypermethylation.
作者信息
Yu Qiang
机构信息
Cancer Biology and Pharmacology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore.
出版信息
Epigenetics. 2008 Nov;3(6):315-7. doi: 10.4161/epi.3.6.7202. Epub 2008 Nov 14.
PMID:19098450
Abstract
Both DNA hypermethylation and Polycomb-mediated histone methylation induce gene silencing in cancer, but largely in two separate paths. Hence, different pharmacologic approaches are required to reactivate genes silenced by distinct epigenetic mechanisms.
摘要
Zotero 插件