Wiley C A, Masliah E, Morey M, Lemere C, DeTeresa R, Grafe M, Hansen L, Terry R
Department of Pathology, University of California, San Diego, La Jolla 92093-0612.
Ann Neurol. 1991 Jun;29(6):651-7. doi: 10.1002/ana.410290613.
Clinical and pathological evidence of subcortical central nervous system (CNS) damage is observed commonly in patients with human immunodeficiency virus (HIV) encephalitis. Whether other CNS regions are also affected has not been well studied. We report neocortical damage in patients with HIV encephalitis. Using quantitative techniques, we demonstrate statistically significant thinning of the neocortex, with a loss of large cortical neurons. Qualitative and quantitative assessments of neocortical neuropil reveal a loss of synaptic density and vacuolation of dendritic processes. Failure to demonstrate an association of these changes with the presence of HIV antigens suggests that neocortical damage may be an indirect effect of HIV infection of the CNS.
在人类免疫缺陷病毒（HIV）脑炎患者中，常可观察到皮质下中枢神经系统（CNS）损伤的临床和病理证据。其他中枢神经系统区域是否也受到影响尚未得到充分研究。我们报告了HIV脑炎患者的新皮质损伤。使用定量技术，我们证明新皮质有统计学上显著的变薄，伴有大型皮质神经元的丢失。对新皮质神经纤维网的定性和定量评估显示突触密度降低和树突过程空泡化。未能证明这些变化与HIV抗原的存在有关联，这表明新皮质损伤可能是HIV感染中枢神经系统的间接效应。
