Loktionov A S, Popovich I G, Zabezhinskiĭ M A, Anisimov V N
Biull Eksp Biol Med. 1991 Apr;111(4):398-400.
The mutation was revealed with substitution of A for T in the second position of the 61 Ha-ras oncogene codon in the DNA of 31 skin tumours (26 papillomas and 5 carcinomas) and in 23 mice treated with 12-O-tetradecanoyl phorbol-13-acetate (TPA). Part of these mice were F progeny (n-6) and F progeny (n-4) following DMBA administration during pregnancy, another part F progeny (n-5) following ENU action on males prior to mating, the rest mice (n-3) did not undergo additional actions. The mutation under study was revealed only in 3 out of 5 papillomas and in all 5 carcinomas of mice subjected to DMBA administration during pregnancy.
在31个皮肤肿瘤（26个乳头状瘤和5个癌）以及23只经12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）处理的小鼠的DNA中，61号Ha - ras癌基因密码子的第二个位置发生了A被T取代的突变。这些小鼠一部分是孕期给予二甲基苯并蒽（DMBA）后的F1代（n = 6）和F2代（n = 4），另一部分是交配前雄性经N - 乙基 - N - 亚硝基脲（ENU）处理后的F1代（n = 5），其余小鼠（n = 3）未经过额外处理。所研究的突变仅在孕期给予DMBA的小鼠的5个乳头状瘤中的3个以及所有5个癌中被发现。
