Sugano Y
Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama, Japan.
Cell Mol Life Sci. 2009 Apr;66(8):1387-403. doi: 10.1007/s00018-008-8651-8.
Dye-decolorizing peroxidase (DyP) is produced by a basidiomycete (Thanatephorus cucumeris Dec 1) and is a member of a novel heme peroxidase family (DyP-type peroxidase family) that appears to be distinct from general peroxidases. Thus far, 80 putative members of this family have been registered in the PeroxiBase database (http://peroxibase.isbsib.ch/) and more than 400 homologous proteins have been detected via PSI-BLAST search. Although few studies have characterized the function and structure of these proteins, they appear to be bifunctional enzymes with hydrolase or oxygenase, as well as typical peroxidase activities. DyP-type peroxidase family suggests an ancient root compared with other general peroxidases because of their widespread distribution in the living world. In this review, firstly, an outline of the characteristics of DyP from T. cucumeris is presented and then interesting characteristics of the DyP-type peroxidase family are discussed.
染料脱色过氧化物酶（DyP）由担子菌（瓜亡革菌Dec 1）产生，是一个新型血红素过氧化物酶家族（DyP型过氧化物酶家族）的成员，该家族似乎与一般过氧化物酶不同。到目前为止，该家族的80个推定成员已在PeroxiBase数据库（http://peroxibase.isbsib.ch/）中注册，并且通过PSI-BLAST搜索检测到400多种同源蛋白。尽管很少有研究对这些蛋白质的功能和结构进行表征，但它们似乎是具有水解酶或加氧酶以及典型过氧化物酶活性的双功能酶。由于DyP型过氧化物酶家族在生物界广泛分布，与其他一般过氧化物酶相比，它显示出古老的起源。在这篇综述中，首先介绍了瓜亡革菌DyP的特征概述，然后讨论了DyP型过氧化物酶家族的有趣特征。
