Ouyang Yan-Qiong, Li Si-Jian, Zhang Qing, Xiang Wen-Pei, Shen Hong-Ling, Chen Han-Ping, Chen Hong, Chen Hui-Zhen
HOPE School of Nursing, Wuhan University, Wuhan 430071, China.
Arch Gynecol Obstet. 2009 Jul;280(1):91-7. doi: 10.1007/s00404-008-0874-2. Epub 2008 Dec 20.
Considerable interest has been focused on angiogenic factors and angiogenic imbalance in the field of pre-eclampsia (PE), owing to its gaining role in the development of PE. This study was addressed to investigate the associations of sFlt-1-to-PlGF plasma ratios with oxidative stress assessed by the level of 8-isoprostane, and inflammation measured by the level of high-sensitive C-reactive protein (hs-CRP), and adipocytokines.
A total of 83 patients with PE including 47 mild PE (MPE) and 36 severe PE (SPE) and 50 age-matched normotensive subjects in the third trimester of pregnancy were examined. Measurements included body mass index (BMI), systolic and diastolic blood pressure (BP) levels, plasma concentrations of hs-CRP, 8-isoprostane, adiponectin, and leptin.
Subjects with PE had higher levels of sFlt-1/PlGF (P < 0.01), hs-CRP (P < 0.01), 8-isoprostane and leptin (both P < 0.01) and lower adiponectin (P < 0.01) than did normotensive control subjects. Significant positive correlations were found between plasma sFlt-1/PlGF and hs-CRP (r = 0.437, P < 0.01) or leptin (r = 0.656, P < 0.01). A weak inverse correlation emerged between sFlt-1/PlGF and adiponectin (r = -0.306, P < 0.01). When a multiple regression analysis was performed, with sFlt-1/PlGF as a dependent variable and all the other parameters as independent variables, sFlt-1/PlGF maintain a significant relationship with leptin (beta = 0.219, P < 0.05) and with hs-CRP (beta = 0.295, P < 0.01) as well as with systolic BP(beta = 0.446, P < 0.05).
In Chinese preeclamptic women, plasma sFlt-1-to-PlGF ratio is correlated with inflammatory and adipocytokines but not with oxidative stress.
由于血管生成因子和血管生成失衡在子痫前期（PE）发病过程中作用日益凸显，该领域已对此予以高度关注。本研究旨在探讨可溶性血管内皮生长因子受体-1（sFlt-1）与胎盘生长因子（PlGF）的血浆比值与通过8-异前列腺素水平评估的氧化应激、通过高敏C反应蛋白（hs-CRP）水平测定的炎症以及脂肪细胞因子之间的关联。
共检查了83例PE患者，其中包括47例轻度PE（MPE）和36例重度PE（SPE），以及50例孕晚期年龄匹配的血压正常的受试者。测量指标包括体重指数（BMI）、收缩压和舒张压（BP）水平、hs-CRP、8-异前列腺素、脂联素和瘦素的血浆浓度。
与血压正常的对照组相比，PE患者的sFlt-1/PlGF水平（P < 0.01）、hs-CRP水平（P < 0.01）、8-异前列腺素和瘦素水平（均P < 0.01）更高，而脂联素水平更低（P < 0.01）。血浆sFlt-1/PlGF与hs-CRP（r = 0.437，P < 0.01）或瘦素（r = 0.656，P < 0.01）之间存在显著正相关。sFlt-1/PlGF与脂联素之间出现弱负相关（r = -0.306，P < 0.01）。当以sFlt-1/PlGF作为因变量，所有其他参数作为自变量进行多元回归分析时，sFlt-1/PlGF与瘦素（β = 0.219，P < 0.05）、hs-CRP（β = 0.295，P < 0.01）以及收缩压（β = 0.446，P < 0.05）均保持显著关系。
在中国子痫前期女性中，血浆sFlt-1与PlGF的比值与炎症和脂肪细胞因子相关，但与氧化应激无关。
