Grimes T M, King D J, Kleven S H, Fletcher O J
Avian Dis. 1977 Jan-Mar;21(1):26-38.
Type-8 avian adenoviruses were isolated from chickens in a commerical flock suffering an outbreak of inclusion body hepatitis. Serum-neutralizing titer to this type, but not to 7 other types of avian adenovirus, was more than 4 times as high in convalescing chickens as in chickens from the flock bled 2 weeks previously, during the disease outbreak. A disease similar to that in the commercial flock and to inclusion body hepatitis as described in the literature was produced by intra-abdominal inoculation of a type-8 isolant, AMG 5 (2a), into 1-day-old specific-pathogen-free chicks. Pathologic features of the disease included necrotizing hepatitis, pancreatitis, and severe lymphoid depletion of the bursa of Fabricius, thymus, and spleen. It was concluded that type-8 avian adenoviruses were involved in the etiology of the naturally occurring outbreak of inclusion body hepatitis.
8型禽腺病毒是从一个发生包涵体肝炎疫情的商业鸡群中分离出来的。在恢复期的鸡中，针对该型病毒的血清中和效价，而非针对其他7种禽腺病毒的血清中和效价，比在疾病爆发期间（即疫情爆发前2周采血的鸡群中的鸡）高出4倍多。通过将8型分离株AMG 5（2a）腹腔接种到1日龄无特定病原体雏鸡中，引发了一种与商业鸡群中疾病以及文献中描述的包涵体肝炎相似的疾病。该疾病的病理特征包括坏死性肝炎、胰腺炎以及法氏囊、胸腺和脾脏的严重淋巴细胞耗竭。得出的结论是，8型禽腺病毒参与了自然发生的包涵体肝炎疫情的病因。
