Wang Yi-Ni, Wang Zhao, Wang Jing-Shi, Feng Cui-Cui, Tian Li-Ping, Wu Lin
Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Dec;16(6):1379-82.
This study was aimed to explore the level of glycosylated ferritin in the patients with secondary hemophagocytic lymphohistiocytosis (HLH) and its diagnostic significance. 29 suspected HLH patients from October 2007 to October 2008 were enrolled in the study, and 25 healthy subjects were selected as control. The 29 suspected HLH patients were divided into confirmed group (22 out of 29) and unconfirmed group (7 out of 29) according to HLH-2004 diagnostic criteria. The percentage of glycosylated ferritin in peripheral blood was determined by phytohemagglutinin adsorption assay. The results showed that the median level of total serum ferritin in patients of confirmed group (2897.6+/-1837.2 microg/L) was significantly higher than that in patients of unconfirmed group (653.1+/-249.1 microg/L) (p<0.01), and was also higher than that in controls (414.6+/-212.6 microg/L) (p<0.01). The median percentage of glycosylated ferritin in patients of confirmed group was significantly lower (17.0+/-4.2%) than that in patients of unconfirmed group (40.7+/-4.5%) (p<0.01) and was lower than that in controls (53.6+/-13.3%) (p<0.01). The sensitivity (86.4% vs 77.3%) and specificity (71.4% vs 42.9%) of glycosylated ferritin for the diagnosis of HLH were higher than that of total serum ferritin. In conclusions, glycosylated ferritin may be a helpful marker for the diagnosis of HLH.
本研究旨在探讨继发性噬血细胞性淋巴组织细胞增生症（HLH）患者糖基化铁蛋白水平及其诊断意义。选取2007年10月至2008年10月的29例疑似HLH患者纳入研究，并选取25例健康受试者作为对照。根据HLH - 2004诊断标准，将29例疑似HLH患者分为确诊组（29例中的22例）和未确诊组（29例中的7例）。采用植物血凝素吸附法测定外周血中糖基化铁蛋白的百分比。结果显示，确诊组患者血清总铁蛋白中位数水平（2897.6±1837.2μg/L）显著高于未确诊组患者（653.1±249.1μg/L）（p<0.01），也高于对照组（414.6±212.6μg/L）（p<0.01）。确诊组患者糖基化铁蛋白中位数百分比（17.0±4.2%）显著低于未确诊组患者（40.7±4.5%）（p<0.01），且低于对照组（53.6±13.3%）（p<0.01）。糖基化铁蛋白诊断HLH的敏感性（86.4%对77.3%）和特异性（71.4%对42.9%）高于血清总铁蛋白。结论：糖基化铁蛋白可能是诊断HLH的有用标志物。
