Su Weiqiang, Jiao Guoqing, Yang Chengjian, Ye Yizhou
Department of Cardiovascular Surgery, Affiliated Wuxi 2nd People's Hospital, Nanjing Medical University, Jiangsu, People's Republic of China.
Clin Biochem. 2009 Mar;42(4-5):365-70. doi: 10.1016/j.clinbiochem.2008.11.010. Epub 2008 Dec 3.
To investigate the possible role of apolipoprotein M (ApoM) in the development of coronary artery disease (CAD).
Case-controlled study, which consisted of 118 CAD patients and 255 unrelated subjects used as control group. Plasma concentration of ApoM was determined by dot blot, severity of CAD was expressed with Gensini score or the numbers of lesioned coronary arteries, and serum lipid levels were also measured.
Our study shows the mean level of plasma ApoM is 1.3757+/-0.1493 ODu mm(-2) in CAD patients, while it is 1.3502+/-0.1288 ODu mm(-2) in control group, and there are significant differences in plasma level of ApoM between two groups (t=0.032, P<0.05). Concentration of plasma ApoM is positively associated with plasma total cholesterol (r=0.38, P=0.025), high density lipoprotein cholesterol (r=0.29, P=0.03), low density lipoprotein cholesterol (r=0.16, P=0.03) and apolipoproein A-I (r=0.24, P=0.03). Multiple logistic and linear regression analysis showed that plasma concentration of ApoM did not correlate either with the number of lesioned coronaries or the Gensini score after adjusted for conventional cardiovascular risk factors (P>0.05, respectively).
The findings suggest that ApoM could not be an independent risk factor but a biomarker of CAD.
探讨载脂蛋白M（ApoM）在冠状动脉疾病（CAD）发生发展中的可能作用。
病例对照研究，包括118例CAD患者和255名无亲缘关系的受试者作为对照组。采用斑点印迹法测定血浆ApoM浓度，用Gensini评分或病变冠状动脉数量表示CAD的严重程度，并测定血脂水平。
我们的研究显示，CAD患者血浆ApoM的平均水平为1.3757±0.1493 ODu mm（-2），而对照组为1.3502±0.1288 ODu mm（-2），两组间血浆ApoM水平存在显著差异（t = 0.032，P < 0.05）。血浆ApoM浓度与血浆总胆固醇（r = 0.38，P = 0.025）、高密度脂蛋白胆固醇（r = 0.29，P = 0.03）、低密度脂蛋白胆固醇（r = 0.16，P = 0.03）和载脂蛋白A-I（r = 0.24，P = 0.03）呈正相关。多元逻辑回归和线性回归分析显示，在调整传统心血管危险因素后，血浆ApoM浓度与病变冠状动脉数量或Gensini评分均无相关性（P均> 0.05）。
研究结果表明，ApoM不是CAD的独立危险因素，而是CAD的一个生物标志物。
