Wu S-W, Chang H-R, Lai Y-R, Lian J-D
Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Transplant Proc. 2008 Dec;40(10):3770-1. doi: 10.1016/j.transproceed.2008.06.100.
Mycophenolate mofetil (MMF) is increasingly used as an immunosuppressant for organ transplantation and for treatment of autoimmune diseases. As yet, the experience with acute overdose of MMF in humans is limited. Herein we have reported a 40-year-old female kidney recipient with moderate leukopenia and lack of gastrointestinal toxicity following ingestion of 25 g MMF, which was confirmed by serum drug levels. We treated the patient with charcoal decontamination and oral cholestyramine. She recovered completely without sequelae.
霉酚酸酯（MMF）越来越多地被用作器官移植的免疫抑制剂和自身免疫性疾病的治疗药物。迄今为止，人类急性过量服用MMF的经验有限。在此，我们报告了一名40岁的女性肾移植受者，她摄入25克MMF后出现中度白细胞减少但无胃肠道毒性，血清药物水平证实了这一点。我们用活性炭去污和口服考来烯胺治疗该患者。她完全康复，没有后遗症。
