兔卵泡成熟过程中生殖泡染色质构型和转录活性的动态变化

Dynamic changes of germinal vesicle chromatin configuration and transcriptional activity during maturation of rabbit follicles.

作者信息

Wang Hui-Li, Sui Hong-Shu, Liu Yong, Miao De-Qiang, Lu Jin-Hua, Liang Bo, Tan Jing-He

机构信息

College of Animal Science & Veterinary Medicine, Shandong Agricultural University, Tai-an City, People's Republic of China.

出版信息

Fertil Steril. 2009 Apr;91(4 Suppl):1589-94. doi: 10.1016/j.fertnstert.2008.10.071. Epub 2008 Dec 18.

DOI:10.1016/j.fertnstert.2008.10.071

PMID:19100534

Abstract

Dynamic changes in configuration of germinal vesicle (GV) chromatin and their effects on oocyte transcriptional activity and developmental competence were studied in rabbit oocytes. The results indicated that global condensation of GV chromatin, rather than the formation of a perinucleolar ring, would better reflect the global transcriptional repression and developmental competence of oocytes. Gonadotropins, by promoting large-scale chromatin remodeling, regulate oocyte transcriptional activity and developmental competence.

摘要

在兔卵母细胞中研究了生发泡（GV）染色质构型的动态变化及其对卵母细胞转录活性和发育能力的影响。结果表明，GV染色质的整体凝聚而非核仁周围环的形成，能更好地反映卵母细胞的整体转录抑制和发育能力。促性腺激素通过促进大规模染色质重塑，调节卵母细胞的转录活性和发育能力。