CD45的可变剪接：冰山一角。
Alternative splicing of CD45: the tip of the iceberg.
作者信息
Zikherman Julie, Weiss Arthur
机构信息
Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA.
出版信息
Immunity. 2008 Dec 19;29(6):839-41. doi: 10.1016/j.immuni.2008.12.005.
PMID:19100695
Abstract
Mechanisms underlying the regulated splicing of CD45 RNA have been long-standing puzzles. In this issue of Immunity, Wu et al. (2008) identify hnRNPLL as a critical regulator of both signal-induced exon skipping in CD45 and global alternative-transcript expression in memory T cells.
摘要
CD45 RNA 可变剪接的潜在机制一直是个长期存在的谜题。在本期《免疫》杂志中，Wu 等人（2008 年）确定 hnRNPLL 是 CD45 中信号诱导外显子跳跃以及记忆 T 细胞中全局可变转录本表达的关键调节因子。
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