HIV-1复制的精英抑制
Elite suppression of HIV-1 replication.
作者信息
Blankson Joel N, Siliciano Robert F
机构信息
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Immunity. 2008 Dec 19;29(6):845-7. doi: 10.1016/j.immuni.2008.12.002.
PMID:19100698
Abstract
Rare HIV-1-infected individuals are able to control viral replication without antiretroviral therapy. In this issue of Immunity, Migueles et al. (2008) show that HIV-1-specific CD8+ T cells from these individuals effectively suppress viral replication by granzyme B-mediated killing of target cells.
摘要
少数感染了HIV-1的个体在不接受抗逆转录病毒治疗的情况下能够控制病毒复制。在本期《免疫》杂志中，米盖莱斯等人（2008年）表明，来自这些个体的HIV-1特异性CD8 + T细胞通过颗粒酶B介导的靶细胞杀伤有效地抑制病毒复制。
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