Waterman Kenneth C, MacDonald Bruce C, Roy Michael C
Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA.
J Control Release. 2009 Mar 19;134(3):201-6. doi: 10.1016/j.jconrel.2008.11.017. Epub 2008 Dec 3.
A new controlled-release, extrudable core system (ECS) tablet has been developed which osmotically delivers high doses of low solubility active pharmaceutical ingredients (API's). The tablet has a single core formed in a modified oval shape with a semi-permeable coating. The core contains hydroxyethylcellulose, which serves to entrain the API particles as they are extruded out a hole in the coating at one end of the tablet, and a sugar, which provides the osmotic driving force for water imbibing. The dosage form has been successfully shown to control delivery of API over a range of delivery rates even with 50% of the tablet being API (up to about 500 mg).
一种新型控释、可挤出核心系统（ECS）片剂已被研发出来，它能以渗透方式递送高剂量低溶解度的活性药物成分（API）。该片剂有一个呈改良椭圆形的单核，并带有半透膜包衣。核心包含羟乙基纤维素，其作用是在API颗粒从片剂一端包衣上的一个孔挤出时夹带这些颗粒，还有一种糖，它为水的吸收提供渗透驱动力。该剂型已成功证明，即使片剂的50%为API（高达约500毫克），也能在一系列释放速率范围内控制API的释放。
