线粒体分裂的分子机制和细胞功能。
The molecular mechanism and cellular functions of mitochondrial division.
作者信息
Lackner Laura L, Nunnari Jodi M
机构信息
Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA.
出版信息
Biochim Biophys Acta. 2009 Dec;1792(12):1138-44. doi: 10.1016/j.bbadis.2008.11.011. Epub 2008 Dec 3.
Abstract
Mitochondria are highly dynamic organelles that continuously divide and fuse. These dynamic processes regulate the size, shape, and distribution of the mitochondrial network. In addition, mitochondrial division and fusion play critical roles in cell physiology. This review will focus on the dynamic process of mitochondrial division, which is highly conserved from yeast to humans. We will discuss what is known about how the essential components of the division machinery function to mediate mitochondrial division and then focus on proteins that have been implicated in division but whose functions remain unclear. We will then briefly discuss the cellular functions of mitochondrial division and the problems that arise when division is disrupted.
摘要
线粒体是高度动态的细胞器，不断进行分裂和融合。这些动态过程调节线粒体网络的大小、形状和分布。此外，线粒体分裂和融合在细胞生理学中发挥着关键作用。本综述将聚焦于线粒体分裂的动态过程，该过程从酵母到人类高度保守。我们将讨论关于分裂机制的关键组成部分如何发挥功能介导线粒体分裂的已知信息，然后聚焦于那些与分裂有关但其功能仍不清楚的蛋白质。接着，我们将简要讨论线粒体分裂的细胞功能以及分裂受到干扰时出现的问题。
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