Hosseini Jalil, Kaviani Ali, Golshan Ali Reza
Division of Reconstructive Urology, Shohada-e-Tajrish Hospital and Urology and Nephrology Research Center, Shahid Beheshti University MC, Tehran, Iran.
Urol J. 2008 Fall;5(4):265-8.
Our aim was to evaluate clean intermittent catheterization (CIC) results in combination with triamcinolone ointment for lubrication of the catheter after internal urethrotomy.
Seventy patients who underwent internal urethrotomy were assigned into 2 groups and performed CIC with either triamcinolone 1% ointment or a water-based gel (control) for lubrication of the catheter. They continued CIC regimen up to 6 month and were followed up for 12 months. Retrograde urethrography and urethrocystoscopy were done 6 and 12 months postoperatively. In case of obstructive symptoms or any difficulty in passing the urethral catheter, internal urethrotomy would be performed, if needed, and the same follow-up protocol would be started again. The recurrence rates after the first and second urethrotomy attempts were compared between the two groups.
Thirty patients in the triamcinolone group and 34 in the control group completed the study. There were no significant differences in the baseline characteristics of the patients or the etiology of the stricture between the two groups. There was a 30.0% recurrence rate in the patients of the triamcinolone group versus 44.1% in those of the control group after the first internal urethrotomy (P = .24). Following the second internal urethrotomy, the urethra was stabilized in 88.9% of the patients in the triamcinolone group and 60.0% those in the control group (P = .15).
Administration of triamcinolone ointment in patients on CIC regimen after internal urethrotomy only slightly decreased the stricture recurrence rate, and its possible effects should be more investigated.
我们的目的是评估在尿道内切开术后，清洁间歇性导尿（CIC）联合曲安奈德软膏用于导管润滑的效果。
70例行尿道内切开术的患者被分为两组，分别使用1%曲安奈德软膏或水性凝胶（对照组）润滑导管进行CIC。他们持续CIC方案长达6个月，并随访12个月。术后6个月和12个月进行逆行尿道造影和尿道膀胱镜检查。如果出现梗阻症状或导尿困难，必要时将再次进行尿道内切开术，并重新开始相同的随访方案。比较两组患者首次和第二次尿道内切开术后的复发率。
曲安奈德组30例患者和对照组34例患者完成了研究。两组患者的基线特征或狭窄病因无显著差异。首次尿道内切开术后，曲安奈德组患者的复发率为30.0%，而对照组为44.1%（P = 0.24）。第二次尿道内切开术后，曲安奈德组88.9%的患者尿道稳定，对照组为60.0%（P = 0.15）。
尿道内切开术后接受CIC方案的患者使用曲安奈德软膏仅略微降低了狭窄复发率，其可能的效果应进一步研究。
