Yang Han-Kwang, Park Do Joong, Lee Hyuk-Joon, Kim Hyung-Ho, Kim Woo Ho, Lee Kuhn Uk
Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Hepatogastroenterology. 2008 Sep-Oct;55(86-87):1925-30.
BACKGROUND/AIMS: This study was undertaken to investigate a surgical role in treating gastrointestinal stromal tumors (GISTs) of the stomach and to find their behavior and prognostic factors.
The clinicopathologic results of 112 patients with gastric GISTs who underwent surgery from December 1999 to August 2006 were reviewed.
Forty (35.7%) patients had no symptoms. Of a total of 112 patients, curative resections were performed on 105 (93.8%). There were 41 (36.6%) high-risk patients. The mean follow-up period was 34.3 months (1-82 months) and there were two deaths. Six (5.7%) of the 105 patients who received curative resections had recurrences and all recurrences occurred only in high-risk patients. Univariate analysis showed that tumor size and mitotic count were prognostic for disease-free survival of GIST patients (p=0.0004 and p<0.0001, respectively), but multivariate analysis identified mitotic count as the only prognostic factor for disease-free survival of GIST patients (p=0.039).
The curative resection rate was high in GISTs of the stomach and they were treated using various surgical procedures. Patient survival after curative resection was good. Mitotic count was the independent prognostic factor for disease-free survival and only high-risk patients had recurrences.
背景/目的：本研究旨在探讨手术在治疗胃胃肠道间质瘤（GIST）中的作用，并了解其生物学行为和预后因素。
回顾性分析1999年12月至2006年8月期间接受手术治疗的112例胃GIST患者的临床病理结果。
40例（35.7%）患者无症状。112例患者中，105例（93.8%）接受了根治性切除。有41例（36.6%）高危患者。平均随访时间为34.3个月（1 - 82个月），有2例死亡。105例接受根治性切除的患者中有6例（5.7%）复发，且所有复发均仅发生在高危患者中。单因素分析显示肿瘤大小和核分裂象计数对GIST患者的无病生存期具有预后意义（分别为p = 0.0004和p < 0.0001），但多因素分析确定核分裂象计数是GIST患者无病生存期的唯一预后因素（p = 0.039）。
胃GIST的根治性切除率较高，采用了多种手术方式进行治疗。根治性切除术后患者生存情况良好。核分裂象计数是无病生存期的独立预后因素，且只有高危患者会复发。
