[湖南省HIV-1耐药阈值的研究]
[Study on the threshold of HIV-1 drug resistance in Hunan province].
作者信息
Chen Xi, Xing Hui, He Jian-mei, Zheng Jun, Zou Xiao-bai, Ruan Yu-hua, Qin Bi-yun, Shao Yi-ming
机构信息
Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China.
出版信息
Zhonghua Liu Xing Bing Xue Za Zhi. 2008 Aug;29(8):787-9.
OBJECTIVE
To survey the prevalence of HIV-1 drug resistance in patients newly diagnosed as HIV positive and who were younger than 25 years of age but had not received treatment with antiretroviral treatment (ART) in Hunan province.
METHODS
Serum specimens of HIV infected individuals were collected and HIV-1 pol genetic mutations associated with drug resistance were identified with PCR and interpreted with Stanford HIV Drug Resistance Database.
RESULTS
A total number of 69 patients whose HIV sequences were amplified successfully with 2 (2.9%) specimens appeared mutations associated with HIV-1 drug resistance in the reverse transcriptase region, including one as V75M and the other one as K103N and V181C. Data showed that the prevalence of drug resistance in Hunan was 2.9%.
CONCLUSION
The first line regiments of national ART seemed still effective. Most of the AIDS patients did not need to be tested on drug resistance status before starting ART. However, it is important to start HIV drug resistance surveillance in no time.
目的
调查湖南省新诊断为HIV阳性且年龄小于25岁但未接受过抗逆转录病毒治疗（ART）的患者中HIV-1耐药情况。
方法
收集HIV感染者血清标本，采用PCR鉴定与耐药相关的HIV-1 pol基因突变，并通过斯坦福HIV耐药数据库进行解读。
结果
共69例患者HIV序列成功扩增，2份（2.9%）标本在逆转录酶区出现与HIV-1耐药相关的突变，其中1份为V75M，另1份为K103N和V181C。数据显示湖南省耐药率为2.9%。
结论
国家ART一线方案似乎仍然有效。大多数艾滋病患者在开始ART前无需进行耐药检测。然而，立即开展HIV耐药监测很重要。
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