[抗生素埃瑞莫霉素部分降解产物的结构与抗菌活性]

[The structure and antimicrobial activity of the partial degradation products of the antibiotic eremomycin].

作者信息

Berdnikova T F, Lomakina N N, Olsuf'eva E N, Aleksandrova L G, Potapova N P, Rozynov B V, Malkova I V, Orlova G I

出版信息

Antibiot Khimioter. 1991 Jun;36(6):28-31.

PMID:1910324

Abstract

Antimicrobial activity of partial degradation products of eremomycin, a new glycopeptide antibiotic, was studied. The products formed by eremomycin deglycosylation (deseremosaminyl eremomycin, eremosaminyl aglycone and aglycone) and elimination of the chlorine atom from the molecule aglycone moiety (dechloroeremomycin). The spectral data in favour of the compounds structure are presented. It was found that partial degradation led to a decrease in the antimicrobial activity of the antibiotic. Dechloreremomycin had the highest activity among the products. Its MIC for the methicillin-resistant strains of Staphylococcus aureus was only twice as low as that of the initial antibiotic.

摘要

研究了新型糖肽抗生素埃瑞霉素部分降解产物的抗菌活性。这些产物是由埃瑞霉素去糖基化形成的（去血清氨基埃瑞霉素、血清氨基苷元和苷元），以及从苷元部分分子中消除氯原子形成的（脱氯埃瑞霉素）。给出了支持这些化合物结构的光谱数据。发现部分降解导致抗生素的抗菌活性降低。脱氯埃瑞霉素在这些产物中活性最高。其对耐甲氧西林金黄色葡萄球菌菌株的最低抑菌浓度仅比初始抗生素低两倍。