Jenhani F, Bardi R, Chammakhi S, Jeddi M, Ayed K
Laboratory of Immunology, Faculty of Medicine, Tunis, Tunisie.
J Autoimmun. 1991 Jun;4(3):553-61. doi: 10.1016/0896-8411(91)90166-a.
The frequency of HLA-DR antigens, as well as the prevalence of islet cell insulin autoantibodies and other autoimmunity disorders, were investigated in Tunisian patients with insulin-dependent diabetes mellitus (IDDM) and were compared with family members (sibs) and healthy control subjects. Cytoplasmic islet cell autoantibodies (ICA) were found in 79 of 175 (45.1%) patients with IDDM, in 23 of 126 (18.25%) unaffected first degree relatives of type I diabetes patients and in only two of 146 (1.3%) control subjects. In 79 ICA positive patients with IDDM, 46.8% presented other evidence of autoimmunity by testing for specific autoantibodies. Insulin autoantibodies were found in 86.9% of healthy ICA-positive sibs. A good correlation between HLA-DR3/DR4 heterozygous phenotypes and the presence of ICA in patients with IDDM and their unaffected sibs was observed in the Tunisian population. In fact, this heterozygous phenotype is found in 63.3% of ICA-positive diabetic patients and in 44.4% of ICA-positive unaffected sibs, whereas, HLA-DR3/DR4 antigens were noted in only 22.9% of ICA-negative diabetic patients and in no ICA-negative unaffected sibs. In these studies, we also summarized the distribution of HLA-DR antigens in patients with IDDM who presented autoimmune disorders other than ICA.
我们对突尼斯胰岛素依赖型糖尿病(IDDM)患者的HLA - DR抗原频率、胰岛细胞胰岛素自身抗体及其他自身免疫性疾病的患病率进行了调查,并与家庭成员(兄弟姐妹)及健康对照者进行了比较。在175例IDDM患者中,有79例(45.1%)检测到细胞质胰岛细胞自身抗体(ICA);在126例I型糖尿病患者的未患病一级亲属中,有23例(18.25%)检测到ICA;而在146例对照者中,仅有2例(1.3%)检测到ICA。在79例ICA阳性的IDDM患者中,通过检测特异性自身抗体,46.8%的患者呈现出其他自身免疫证据。在健康的ICA阳性兄弟姐妹中,86.9%检测到胰岛素自身抗体。在突尼斯人群中,观察到IDDM患者及其未患病兄弟姐妹中HLA - DR3/DR4杂合表型与ICA的存在之间存在良好的相关性。实际上,在63.3%的ICA阳性糖尿病患者和44.4%的ICA阳性未患病兄弟姐妹中发现了这种杂合表型,而在仅22.9%的ICA阴性糖尿病患者中发现了HLA - DR3/DR4抗原,在ICA阴性的未患病兄弟姐妹中未发现该抗原。在这些研究中,我们还总结了出现除ICA之外自身免疫性疾病的IDDM患者中HLA - DR抗原的分布情况。