Panà A, D'Arca S U, Castello C, Maldarizzi B
Boll Ist Sieroter Milan. 1976 Mar;55(71):18-22.
A serological study of determine the prevalence of infections caused by human Polyoma-virus (BK strain) among the healthy population of Rome has been performed. Such virus was originally isolated from a patient undergoing a kidney transplantation, and later found in patients undergoing immunosuppressive therapy. Previous serological studies showed high incidences of infections, caused by this virus, in human populations. Other viruses, antigenically related, were found in patients suffering from progressive multifocal leukoencephalopathy. Serum samples coming from 482 healthy subjects classified by age and 100 cord blood serum samples were analyzed for antibody titers using haemoagglutination-inhibition and complement fixation tests. High incidence of infection caused by BK virus in the Roman population was found: specifically the haeomagglutination-inhibition test resulted positive in 65.2% of the samples. A remarkable similar trend between the results obtained with both the techniques was observed, although differences in antibody serum levels were present. The infections, which are not transmitted during the intrauterine life, are first noted at about two years of age. The Authors finally briefly discuss the possible epidemiological meaning of the spreading of this infection.
已开展一项血清学研究，以确定罗马健康人群中由人多瘤病毒（BK株）引起的感染患病率。这种病毒最初是从一名接受肾移植的患者中分离出来的，后来在接受免疫抑制治疗的患者中发现。先前的血清学研究表明，该病毒在人群中引起的感染发生率很高。在患有进行性多灶性白质脑病的患者中发现了其他抗原相关病毒。使用血凝抑制和补体结合试验分析了来自按年龄分类的482名健康受试者的血清样本和100份脐带血血清样本的抗体滴度。发现罗马人群中BK病毒引起的感染发生率很高：具体而言，血凝抑制试验在65.2%的样本中呈阳性。尽管存在抗体血清水平差异，但观察到两种技术获得的结果之间有显著相似趋势。这些感染在子宫内生活期间不会传播，首次发现于大约两岁时。作者最后简要讨论了这种感染传播可能的流行病学意义。
