Lalwani A K, Engelstad B L, Boles R
Department of Otolaryngology-Head and Neck Surgery, University of California 94143-0342.
Arch Otolaryngol Head Neck Surg. 1991 Oct;117(10):1138-43. doi: 10.1001/archotol.1991.01870220086015.
The localization of occult infection is often a difficult clinical problem. In 1975, labeling of leukocytes with indium In 111 became technically feasible, and subsequent clinical experience with 111In-labeled leukocyte scanning demonstrated high sensitivity and specificity for acute infection. To our knowledge, experience with white blood cell scanning in the head and neck has not been previously reported. The University of California, San Francisco, experience with 111In-labeled white blood cell scanning was reviewed. Between 1982 and 1987, 520 whole-body 111In-labeled leukocyte studies were performed, of which 60% were interpreted as abnormal. Eighteen studies were abnormal in the head and neck region, and the medical records of these patients were retrospectively reviewed. Abnormal findings correlated with other evidence of disease that involved mucosal surfaces, the neck, and the mediastinum. Sites in the nasopharynx with nasogastric tubes and tracheotomy sites were abnormal without associated clinical evidence of infection. Further clinical experience is needed to correlate white blood cell scan findings with disease in the head and neck and to define the role of the scan in diagnosis and management of otolaryngological disorders.
隐匿性感染的定位常常是一个棘手的临床问题。1975年，用铟In 111标记白细胞在技术上变得可行，随后111In标记白细胞扫描的临床经验表明其对急性感染具有高敏感性和特异性。据我们所知，此前尚未有头颈部白细胞扫描的相关报道。我们回顾了加利福尼亚大学旧金山分校111In标记白细胞扫描的经验。1982年至1987年间，共进行了520例全身111In标记白细胞研究，其中60%的结果被判定为异常。18例研究在头颈部区域出现异常，我们对这些患者的病历进行了回顾性分析。异常发现与涉及黏膜表面、颈部和纵隔的其他疾病证据相关。置有鼻胃管的鼻咽部和气管切开部位出现异常，但无相关感染的临床证据。需要进一步的临床经验来将白细胞扫描结果与头颈部疾病相关联，并确定该扫描在耳鼻喉科疾病诊断和管理中的作用。
