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pH对尼古丁和一甲基碘化尼古丁对大鼠膈肌标本活性的影响。

Effects of ph on the activity of nicotine and nicotine monomethiodide on the rat diaphragm preparation.

作者信息

Barlow R B, Hamilton J T

出版信息

Br J Pharmacol Chemother. 1962 Jun;18(3):543-9. doi: 10.1111/j.1476-5381.1962.tb01173.x.

Abstract

Results have been obtained which substantiate the view that it is the univalent nicotinium ion rather than the un-ionized base which acts at the neuromuscular junction.

摘要

已获得的结果证实了这样一种观点,即在神经肌肉接头处起作用的是一价烟碱离子而非未离子化的碱。

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本文引用的文献

1
Ionization, pH and biological activity.
Pharmacol Rev. 1952 Jun;4(2):136-67.
2
Local anesthetics. I. The blocking potencies of some local anesthetics and of butyl alcohol determined on peripheral nerves.
Acta Pharmacol Toxicol (Copenh). 1954;10(3):281-91. doi: 10.1111/j.1600-0773.1954.tb01344.x.
3
Nicotine monomethiodide.
J Pharm Pharmacol. 1955 Jan;7(1):27-34. doi: 10.1111/j.2042-7158.1955.tb12000.x.

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