Petersen Lars F, Ninomiya Hiromasa, Winklbauer Rudolf
Department of Cell & Systems Biology, University of Toronto, Toronto, ON, Canada.
Methods Mol Biol. 2008;469:477-84. doi: 10.1007/978-1-60327-469-2_30.
Non-canonical Wnt signaling is an important regulator of gastrulation in Xenopus. In particular, it has been implicated in the control of convergent extension movements. Convergent extension in the gastrula occurs primarily in the dorsal tissue of the marginal zone, and explants of this tissue will continue to undergo these movements in isolation. This observation has led to an assay to examine convergent extension movements that is unique to the Xenopus system, and is described herein.
非经典Wnt信号通路是非洲爪蟾原肠胚形成过程中的重要调节因子。具体而言，它与趋同延伸运动的控制有关。原肠胚中的趋同延伸主要发生在边缘区的背侧组织，该组织的外植体在离体状态下会继续进行这些运动。这一观察结果催生了一种专门用于检测非洲爪蟾系统中独特的趋同延伸运动的分析方法，本文将对此进行描述。
