膜裂变的要点
The long and short of membrane fission.
作者信息
Roux Aurélien, Antonny Bruno
机构信息
Laboratoire Physico-Chimie Curie, CNRS, Institut Curie, 75248 Paris Cedex 05, France.
出版信息
Cell. 2008 Dec 26;135(7):1163-5. doi: 10.1016/j.cell.2008.12.003.
PMID:19109885
Abstract
During membrane fission, the GTPase dynamin forms helical assemblies at the neck of membrane buds. Although it has been proposed that fission results from the constriction of the dynamin helix, new work by Bashkirov et al. (2008) and Pucadyil and Schmid (2008) unexpectedly shows that helix disassembly is also necessary for membrane fission.
摘要
在膜裂变过程中，GTP酶发动蛋白在膜芽的颈部形成螺旋状聚集体。尽管有人提出裂变是由发动蛋白螺旋结构的收缩导致的，但巴什基罗夫等人（2008年）以及普卡迪尔和施密德（2008年）的新研究意外地表明，螺旋结构的拆解对于膜裂变也是必要的。
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