美西多宁和3-羟基吡啶乙酰半胱氨酸在实验性糖尿病合并外源性高胆固醇血症的脑缺血背景下的神经保护活性。
Neuroprotective activity of mexidole and 3-hydroxypyridine acetylcysteinate against the background of cerebral ischemia in the complex of experimental diabetes mellitus and exogenous hypercholesterolemia.
作者信息
Inchina V I, Bukina S J
机构信息
N. P. Ogarev Mordovian State University.
出版信息
Bull Exp Biol Med. 2008 Jun;145(6):738-40. doi: 10.1007/s10517-008-0190-7.
PMID:19110565
Abstract
We studied the interaction of mexidol and 3-hydroxypyridine acetylcysteinate on the model of experimental ischemic stroke in rats. The preparations were effective in a dose 50 mg/kg (10-day treatment): they reduced the incidence of neurological disturbances (pareses, sensitivity disturbances) and improved antioxidant defense of the plasma.
摘要
我们在大鼠实验性缺血性中风模型上研究了美西多宁和3-羟基吡啶乙酰半胱氨酸的相互作用。这些制剂在剂量为50 mg/kg（治疗10天）时有效：它们降低了神经功能障碍（轻瘫、感觉障碍）的发生率，并改善了血浆的抗氧化防御能力。
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