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造血微环境的基质克隆前体及其在间充质干细胞层级中的地位。

Stromal clonogenic precursors of hemopoietic microenvironment and their rank in the hierarchy of mesenchymal stem cells.

作者信息

Nifontova I N, Svinareva D A, Drize N J

机构信息

Hematology Research Center, Russian Academy of Medical Sciences, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2008 Apr;145(4):544-7. doi: 10.1007/s10517-008-0137-z.

DOI:10.1007/s10517-008-0137-z
PMID:19110613
Abstract

The hierarchy of stromal precursor cells was studied. Changes in the number of fibroblast CFU in foci forming in irradiated recipients were analyzed. These precursor cells are most close known descendants of mesenchymal stem cells, while inducible precursors rank lower in the hierarchy and are the cells directly enlarging the hemopoietic area in irradiated recipients.

摘要

研究了基质前体细胞的层次结构。分析了在受辐照受体中形成的灶性区域内成纤维细胞集落形成单位(CFU)数量的变化。这些前体细胞是间充质干细胞最知名的后代,而诱导性前体细胞在层次结构中排名较低,是直接扩大受辐照受体造血区域的细胞。

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