Carney S L
Lilly Research Centre Ltd., Eli Lilly & Co., Windlesham, Surrey, UK.
Curr Opin Rheumatol. 1991 Aug;3(4):669-75. doi: 10.1097/00002281-199108000-00019.
Over the past 20 years, there has been growing interest in the biochemistry, molecular biology, and physiology of cartilage. In the last year, there have been considerable advances in the understanding of the processes involved in the anabolism and breakdown of cartilage and the influence of cytokines and growth factors. This review addresses the area of cartilage research, the investigation of markers of cartilage, and the biochemical mechanisms involved in the development of osteoarthritis in animal models. The volume of cartilage research is extensive, and due to the nature of this review, I concentrate on work that is directly related to the anabolic and catabolic response of cartilage to various agents and to those investigations of cartilage with particular relevance to the development of osteoarthritis both in experimental models and in humans.
在过去20年里，人们对软骨的生物化学、分子生物学和生理学的兴趣与日俱增。在过去一年中，我们对软骨合成代谢和分解代谢过程以及细胞因子和生长因子的影响有了相当大的进展。本综述阐述了软骨研究领域、软骨标志物的研究以及动物模型中骨关节炎发生发展所涉及的生化机制。软骨研究的数量众多，鉴于本综述的性质，我将重点关注与软骨对各种因素的合成代谢和分解代谢反应直接相关的研究，以及那些在实验模型和人类中与骨关节炎发展特别相关的软骨研究。
