Hirsch Ranella J, Stier Meghan
Boston University School of Medicine, Department of Dermatology, Boston, MA, USA.
J Drugs Dermatol. 2008 Sep;7(9):841-5.
The wide variety of dermal fillers presently available has revolutionized treatment options for patients seeking a refreshed appearance. Soft tissue fillers include both bovine and human collagens, the hyaluronans, calcium hydroxyapatite, poly-L-lactic acid, and synthetic polymers. However, soft tissue augmentation is never risk-free, and as these procedures have increased in prevalence, complications have been more frequently reported. This article describes a range of complications resulting from dermal filler injections, reviews key case studies, and discusses possible treatment options for adverse effects. While biodegradable fillers offer the least risk for the patient, location, allergic reactions, granulomas, necrosis, and infection are all serious complications that must be considered before performing soft tissue augmentation with any approved dermal filler.
目前市面上各种各样的真皮填充剂彻底改变了那些希望面容焕然一新的患者的治疗选择。软组织填充剂包括牛胶原蛋白和人胶原蛋白、透明质酸、羟基磷灰石钙、聚左旋乳酸以及合成聚合物。然而，软组织填充并非毫无风险，随着这些手术的普及，并发症的报道也越来越频繁。本文描述了真皮填充剂注射引发的一系列并发症，回顾了关键的病例研究，并讨论了不良反应可能的治疗方案。虽然可生物降解的填充剂对患者的风险最小，但在使用任何已获批的真皮填充剂进行软组织填充之前，部位、过敏反应、肉芽肿、坏死和感染都是必须考虑的严重并发症。
