Cylwik Bogdan, Chrostek Lech, Szmitkowski Maciej
Uniwersytet Medyczny w Białymstoku, Zakład Diagnostyki Biochemicznej.
Pol Merkur Lekarski. 2008 Sep;25(147):273-5.
Chronic alcohol consumption increases body iron stores. Patients with alcoholic liver disease frequently exhibit iron overload, but mechanisms of its accumulation remain unclear. Many novel iron-regulatory proteins have been identified for several last years, which have improved understanding the underlying some mechanisms of iron overload in alcoholic liver disease. In this paper, the effect of alcohol on hepcidin expression which is a key hormone in the regulation of iron metabolism has been given. Hepcidin regulates of iron metabolism by inhibiting intestinal iron absorption and the release of iron from macrophages. Alcohol was found to down-regulate hepcidin expression in the liver leading to elevated expression of the iron transporter proteins, DMT1 and ferroportin in the duodenum. Ethanol-mediated oxidative stress inhibits C/EBPaz DNA-binding activity and down-regulates hepcidin transcription in the liver. Deregulation of the hormone synthesis may be one of the causes of iron overload during chronic alcohol consumption.
长期饮酒会增加体内铁储存。酒精性肝病患者常表现出铁过载，但其蓄积机制仍不清楚。在过去几年中，许多新的铁调节蛋白已被鉴定出来，这有助于加深对酒精性肝病中铁过载潜在机制的理解。本文阐述了酒精对铁调素表达的影响，铁调素是铁代谢调节中的关键激素。铁调素通过抑制肠道铁吸收和巨噬细胞铁释放来调节铁代谢。研究发现，酒精会下调肝脏中铁调素的表达，导致十二指肠中铁转运蛋白二价金属离子转运体1（DMT1）和铁转运蛋白的表达升高。乙醇介导的氧化应激会抑制肝脏中C/EBPα的DNA结合活性，并下调铁调素转录。激素合成失调可能是长期饮酒期间铁过载的原因之一。
