Nicasio Anthony M, Tessier Pamela R, Nicolau David P, Knauft R Fredrick, Russomanno John, Shore Eric, Kuti Joseph L
Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut 06102, USA.
Antimicrob Agents Chemother. 2009 Mar;53(3):1218-20. doi: 10.1128/AAC.01386-08. Epub 2008 Dec 29.
By way of bronchoscopy and bronchoalveolar lavage, intrapulmonary steady-state concentrations of micafungin administered at 150 mg daily to 15 healthy volunteers were determined at 4, 12, and 24 h after the third dose. The micafungin disposition was predominantly intracellular, with approximately 106% penetration into alveolar macrophages and 5% penetration into epithelial lining fluid.
通过支气管镜检查和支气管肺泡灌洗,在15名健康志愿者每日服用150mg米卡芬净后的第3剂后4小时、12小时和24小时,测定了肺内稳态浓度。米卡芬净的分布主要在细胞内,约106%渗透到肺泡巨噬细胞中,5%渗透到上皮衬液中。