阿尼芬净和米卡芬净的人体组织分布。
Human Tissue Distribution of Anidulafungin and Micafungin.
机构信息
Clinical Pharmacokinetics Unit, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria.
Department of Pathology, Medical University of Innsbruck, Innsbruck, Austria.
出版信息
Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0016921. doi: 10.1128/AAC.00169-21.
Abstract
Concentrations of anidulafungin and micafungin were determined in eight different tissues obtained during autopsy of four deceased individuals who had been treated with anidulafungin and of seven who had received micafungin. The largest amounts were recovered from liver, with anidulafungin concentrations of 11.01 to 66.50 μg/g and micafungin levels of 0.36 to 5.53 μg/g (0.65 μg/g 30 days after the last administration). The lowest anidulafungin levels were measured in skeletal muscle, and the lowest micafungin concentrations were in kidneys.
摘要
在对四名接受安纳度胺治疗和七名接受米卡芬净治疗的已故患者进行尸检时，检测了 8 种不同组织中的安纳度胺和米卡芬净浓度。从肝脏中回收的量最大，安纳度胺浓度为 11.01 至 66.50μg/g，米卡芬净水平为 0.36 至 5.53μg/g（末次给药后 30 天为 0.65μg/g）。在骨骼肌中测量到的安纳度胺水平最低，而在肾脏中米卡芬净浓度最低。
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