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低剂量左旋布比卡因(0.1%)采用多次神经刺激用于腋神经丛阻滞的疗效。

Efficacy of low dose levobupivacaine (0.1%) for axillary plexus block using multiple nerve stimulation.

作者信息

Zhao X, Wang Y W, Chen H, Zhang Z, You X M, Luo K, Jin Y J

机构信息

Department of Anaesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

出版信息

Anaesth Intensive Care. 2008 Nov;36(6):850-4. doi: 10.1177/0310057X0803600616.

Abstract

The purpose of this study was to investigate if low doses of levobupivacaine (0.1%) produce complete sensory blockade in preoperative axillary brachial plexus block and to compare the effect of different doses of levobupivacaine on sensory and motor blockade. A total of 110 patients scheduled for elective forearm or hand surgery were randomly allocated to receive 36 ml or 72 ml of levobupivacaine 0.1% or 36 ml of levobupivacaine 0.25%. In each group, volumes were equally distributed in the four nerve territories. In all patients, the sensory and motor block was assessed at five, 10, 20 and 30 minutes after the placement of axillary block. Complete sensory block was obtained in 94.4% of patients receiving 36 ml of levobupivacaine 0.1%, 92.1% of those receiving 72 ml of levobupivacaine 0.1%, and 97.1% of those receiving 36 ml of levobupivacaine 0.25%. There was no significant difference either in the onset of the sensory and motor block or duration of the sensory and motor block. This study demonstrates that 36 ml of levobupivacaine 0.1% (36 mg) is as effective as higher doses and volumes in axillary brachial plexus blockade.

摘要

本研究的目的是调查低剂量左旋布比卡因(0.1%)在术前腋路臂丛神经阻滞中是否能产生完全的感觉阻滞,并比较不同剂量的左旋布比卡因对感觉和运动阻滞的影响。总共110例计划进行择期前臂或手部手术的患者被随机分配接受36毫升0.1%的左旋布比卡因、72毫升0.1%的左旋布比卡因或36毫升0.25%的左旋布比卡因。在每组中,容量在四个神经区域平均分配。对所有患者在腋路阻滞放置后5、10、20和30分钟评估感觉和运动阻滞情况。接受36毫升0.1%左旋布比卡因的患者中94.4%获得了完全感觉阻滞,接受72毫升0.1%左旋布比卡因的患者中92.1%获得了完全感觉阻滞,接受36毫升0.25%左旋布比卡因的患者中97.1%获得了完全感觉阻滞。感觉和运动阻滞的起效时间或感觉和运动阻滞的持续时间均无显著差异。本研究表明,36毫升0.1%(36毫克)的左旋布比卡因在腋路臂丛神经阻滞中与更高剂量和容量的效果相同。

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